{"id":1984,"date":"2020-10-20T08:22:42","date_gmt":"2020-10-20T08:22:42","guid":{"rendered":"https:\/\/repo.epiprev.it\/?p=1984"},"modified":"2020-10-20T08:22:42","modified_gmt":"2020-10-20T08:22:42","slug":"effect-of-timing-of-implementation-of-the-lockdown-on-the-number-of-deaths-for-covid-19-in-four-european-countries","status":"publish","type":"post","link":"https:\/\/repo.epiprev.it\/index.php\/2020\/10\/20\/effect-of-timing-of-implementation-of-the-lockdown-on-the-number-of-deaths-for-covid-19-in-four-european-countries\/","title":{"rendered":"Effect of timing of implementation of the lockdown on the number of deaths for COVID-19 in four European countries"},"content":{"rendered":"\n<p class=\"has-small-font-size\"><strong>Publication date:<\/strong> 20\/10\/2020 &#8211;  <strong>E&amp;P Code:<\/strong>  <a aria-label=\" (opens in a new tab)\" rel=\"noreferrer noopener\" href=\"https:\/\/repo.epiprev.it\/1984\" target=\"_blank\">repo.epiprev.it\/1984<\/a>   <br><strong>Authors:<\/strong> Raffaele Palladino<sup>1,2,3<\/sup>, Jordy Bollon<sup>4<\/sup>, Luca Ragazzoni<sup>4,5<\/sup>, Francesco Barone-Adesi<sup>4,5<\/sup><\/p>\n\n\n\n<p class=\"has-small-font-size\"><strong>Abstract<\/strong>: <strong>Background<\/strong>: Lockdown in France, Italy, Spain and United Kingdom, the four European countries which have been impacted the most by the COVID-19 emergency, was enforced 13 to 16 days after the one in Hubei, when normalizing for the time when the outbreak hit 50 cases in all countries. This prompts the question on how many deaths for COVID-19 could have been avoided during the early phase of the pandemic, had containment measures in European countries aligned in timing with those adopted in China.<br><strong>Methods<\/strong>: We modeled the daily number of COVID-19 deaths in France, Italy, Spain, United Kingdom and we estimated the effect of the national lockdown implementing an interrupted time series analysis. Then, we created four separate counterfactual scenario by predicting the daily number of deaths that would have been observed in the four countries if the lockdown had been implemented at the same time as in Hubei. Finally, we estimated the relative change in the number of total deaths in the counterfactual scenario, compared to the observed one.<br><strong>Results<\/strong>: If an early lockdown had been implemented, the death toll would have been 2461, 6769, 6792 and 4071, corresponding to a 92% (95%CI: 86% to 95%), 81% (95%CI: 77% to 84%), 78% (95%CI: 62% to 86%) and 90% (95%CI: 88% to 92%) relative reduction, as compared with observed data.<br><strong>Conclusions<\/strong>: We found that a more rapid and homogeneous response would have avoided a substantial number of deaths. Our results underline the need of strengthening public health emergency preparedness at national and global level.<\/p>\n\n\n\n<!--more-->\n\n\n\n<p class=\"has-small-font-size\"><strong>Cite as<\/strong>: Elenco autori, et. al. (2020). Effect of timing of implementation of the lockdown on the number of deaths for COVID-19 in four European countries. E&P Repository <a href='https:\/\/repo.epiprev.it\/1984'>https:\/\/repo.epiprev.it\/1984<\/a><button title=\"Copia citazione\" id=\"copyTextCite\"><span class=\"far fa-copy\"><\/span><\/button><\/p>\n\n\n\n<p class=\"has-small-font-size\"><strong>Topic<\/strong>: <a href='\/index.php\/category\/COVID-19'>COVID-19<\/a><\/p>\n\n\n\n<p class=\"has-small-font-size\"><strong>Key words<\/strong>: <a href=\"https:\/\/repo.epiprev.it\/index.php\/tag\/covid-19\/\" rel=\"tag\">COVID-19<\/a>, <a href=\"https:\/\/repo.epiprev.it\/index.php\/tag\/eccesso-di-mortalita\/\" rel=\"tag\">eccesso di mortalit\u00e0<\/a>, <a href=\"https:\/\/repo.epiprev.it\/index.php\/tag\/lockdown\/\" rel=\"tag\">lockdown<\/a>, <\/p>\n\n\n\n<p class=\"has-small-font-size\"><strong>AVVERTENZA. GLI ARTICOLI PRESENTI NEL REPOSITORY NON SONO SOTTOPOSTI A PEER REVIEW.<\/strong><\/p>\n\n\n\n<div class='w3eden'><!-- WPDM Link Template: Default Template -->\n\n\n<div class=\"link-template-default card mb-2\">\n    <div class=\"card-body\">\n        <div class=\"media stack-xs\">\n            <div class=\"media-body\">\n                <div class=\"media\">\n                    <div class=\"mr-3 img-48\"><img decoding=\"async\" class=\"wpdm_icon\" alt=\"Icona\" src=\"https:\/\/repo.epiprev.it\/wp-content\/plugins\/download-manager\/assets\/file-type-icons\/pdf.svg\" onError='this.src=\"https:\/\/repo.epiprev.it\/wp-content\/plugins\/download-manager\/assets\/file-type-icons\/unknown.svg\";' \/><\/div>\n                    <div class=\"media-body\">\n                        <h3 class=\"package-title\"><a href='https:\/\/repo.epiprev.it\/index.php\/download\/effect-of-timing-of-implementation-of-the-lockdown-on-the-number-of-deaths-for-covid-19-in-four-european-countries\/'>Effect of timing of implementation of the lockdown on the number of deaths for COVID-19 in four European countries<\/a><\/h3>\n                        <div class=\"text-muted text-small\"><i class=\"fas fa-file-download\"><\/i> 47 Download <i class=\"fas fa-hdd ml-3\"><\/i> 303.32 KB<\/div>\n                    <\/div>\n                <\/div>\n            <\/div>\n            <div class=\"ml-3 wpdmdl-btn\">\n                <a class='wpdm-download-link btn btn-primary ' rel='nofollow' href='#' onclick=\"location.href='https:\/\/repo.epiprev.it\/index.php\/download\/effect-of-timing-of-implementation-of-the-lockdown-on-the-number-of-deaths-for-covid-19-in-four-european-countries\/?wpdmdl=1986&refresh=69e9416cea9161776894316';return false;\">Scarica<\/a>\n            <\/div>\n        <\/div>\n\t\t\n    <\/div>\n<\/div>\n\n\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\">Info<\/h4>\n\n\n\n<p class=\"has-small-font-size\"><strong>Affiliations<\/strong>: <br><sup>1<\/sup> Department of Public Health, University \u201cFederico II\u201d of Naples, Italy<br><sup>2<\/sup> Department of Primary Care and Public Health, Imperial College, London, the UK<br><sup>3<\/sup> CIRMIS\u2014Interdepartmental Center for Research in Healthcare Management and Innovation in Healthcare, University \u201cFederico II\u201d of Naples, Italy<br><sup>4<\/sup> Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy<br><sup>5<\/sup> CRIMEDIM \u2013 Research Center in Emergency and Disaster Medicine, Universit\u00e0 del Piemonte Orientale, Novara, Italy.<\/p>\n\n\n\n<p class=\"has-small-font-size\"><strong>Authors&#8217; contributions: <\/strong>&#8211;<\/p>\n\n\n\n<p class=\"has-small-font-size\"><strong>Competing interests: <\/strong>none.<\/p>\n\n\n\n<p class=\"has-small-font-size\"><strong>Funding disclosure:<\/strong> none.<\/p>\n\n\n\n<p class=\"has-small-font-size\"><strong>Ethics committee approval: <\/strong>The study was based on publicly available aggregate data. No Ethics committee approval was necessary. <\/p>\n\n\n\n<p class=\"has-small-font-size\"><strong>Copyright<\/strong>:  Il detentore del copyright \u00e8 l\u2019autore\/finanziatore, che ha concesso a \u201cE&amp;P Repository\u201d una licenza per rendere pubblico questo preprint. The copyright holder for this preprint is the author\/funder, who has granted E&amp;P Repository a license to display the preprint in perpetuity.<\/p>\n\n\n\n<p class=\"has-small-font-size\"><strong>Terms of distribution<\/strong>: <a rel=\"noreferrer noopener\" href=\"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/deed.it\" target=\"_blank\">CC BY-NC-ND<\/a><\/p>\n\n\n\n<hr \/><img src='https:\/\/repo.epiprev.it\/wp-content\/uploads\/2020\/10\/Barone-Adesi.jpg' alt=\"Barone-Adesi\" class='attachment-post-thumbnail size-post-thumbnail wp-post-image' \/><p class='has-small-font-size'>Fig.1 - Observed (gray points), fitted (black line) and predicted (dashed line) number of new\ndeaths in France, Italy, Spain and United Kingdom, assuming an early implementation of the national\nlockdown (3 days after the outbreak hit 50 cases in each country). Observed points were averaged\nover 3 days.<\/p><hr \/>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-background has-small-font-size has-light-gray-background-color\"><strong>References &amp; Citations<\/strong><br><a rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\" href=\"https:\/\/scholar.google.com\/scholar?q=Effect of timing of implementation of the lockdown on the number of deaths for COVID-19 in four European countries\" target=\"_blank\">Google Scholar<\/a><\/p>\n\n\n\n<p><a href=\"http:\/\/www.facebook.com\/sharer.php?u=https:\/\/www.repo.epiprev.it\/1984\" target=\"_blank\" rel=\"noopener noreferrer\" title=\"Condividi su Facebook\"><img decoding=\"async\" src=\"\/wp-content\/uploads\/2020\/04\/icon_facebook.png\"><\/a><a href=\"https:\/\/twitter.com\/intent\/tweet?url=https:\/\/www.repo.epiprev.it\/1984\" target=\"_blank\" rel=\"noopener noreferrer\" title=\"Condividi su Twitter\"><img decoding=\"async\" src=\"\/wp-content\/uploads\/2020\/04\/icon_twitter.png\"><\/a><a class=\"icon_whatsapp\" href=\"https:\/\/api.whatsapp.com\/send?text=https%3A%2F%2Frepo.epiprev.it\/1984&amp;attribution=AMPhtml&amp;url=https%3A%2F%2Frepo.epiprev.it\/1984\" target=\"_blank\" rel=\"noopener noreferrer\" title=\"Invia con WhatsApp\"><img decoding=\"async\" src=\"\/wp-content\/uploads\/2020\/04\/icon_whatsapp.png\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>We found that a more rapid and homogeneous response would have avoided a substantial number of deaths. Our results underline the need of strengthening public health emergency preparedness at national and global level.<\/p>\n","protected":false},"author":1,"featured_media":1987,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[16,119,118],"class_list":["post-1984","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-covid-19","tag-covid-19","tag-eccesso-di-mortalita","tag-lockdown"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Effect of timing of implementation of the lockdown on the number of deaths for COVID-19 in four European countries - E&amp;P Repository<\/title>\n<meta name=\"description\" content=\"We found that a more rapid and homogeneous response would have avoided a substantial number of deaths. Our results underline the need of strengthening public health emergency preparedness at national and global level.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/repo.epiprev.it\/index.php\/2020\/10\/20\/effect-of-timing-of-implementation-of-the-lockdown-on-the-number-of-deaths-for-covid-19-in-four-european-countries\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Effect of timing of implementation of the lockdown on the number of deaths for COVID-19 in four European countries - E&amp;P Repository\" \/>\n<meta property=\"og:description\" content=\"We found that a more rapid and homogeneous response would have avoided a substantial number of deaths. Our results underline the need of strengthening public health emergency preparedness at national and global level.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/repo.epiprev.it\/index.php\/2020\/10\/20\/effect-of-timing-of-implementation-of-the-lockdown-on-the-number-of-deaths-for-covid-19-in-four-european-countries\/\" \/>\n<meta property=\"og:site_name\" content=\"E&amp;P Repository\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/epiprev\/\" \/>\n<meta property=\"article:published_time\" content=\"2020-10-20T08:22:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/repo.epiprev.it\/wp-content\/uploads\/2020\/10\/Barone-Adesi.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"686\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"administrator\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"administrator\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/repo.epiprev.it\/index.php\/2020\/10\/20\/effect-of-timing-of-implementation-of-the-lockdown-on-the-number-of-deaths-for-covid-19-in-four-european-countries\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/repo.epiprev.it\/index.php\/2020\/10\/20\/effect-of-timing-of-implementation-of-the-lockdown-on-the-number-of-deaths-for-covid-19-in-four-european-countries\/\"},\"author\":{\"name\":\"administrator\",\"@id\":\"https:\/\/repo.epiprev.it\/#\/schema\/person\/2a184e8c4e97508ef5111e78c8d0a59c\"},\"headline\":\"Effect of timing of implementation of the lockdown on the number of deaths for COVID-19 in four European countries\",\"datePublished\":\"2020-10-20T08:22:42+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/repo.epiprev.it\/index.php\/2020\/10\/20\/effect-of-timing-of-implementation-of-the-lockdown-on-the-number-of-deaths-for-covid-19-in-four-european-countries\/\"},\"wordCount\":459,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/repo.epiprev.it\/#organization\"},\"image\":{\"@id\":\"https:\/\/repo.epiprev.it\/index.php\/2020\/10\/20\/effect-of-timing-of-implementation-of-the-lockdown-on-the-number-of-deaths-for-covid-19-in-four-european-countries\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/repo.epiprev.it\/wp-content\/uploads\/2020\/10\/Barone-Adesi.jpg\",\"keywords\":[\"COVID-19\",\"eccesso di mortalit\u00e0\",\"lockdown\"],\"articleSection\":[\"COVID-19\"],\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/repo.epiprev.it\/index.php\/2020\/10\/20\/effect-of-timing-of-implementation-of-the-lockdown-on-the-number-of-deaths-for-covid-19-in-four-european-countries\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/repo.epiprev.it\/index.php\/2020\/10\/20\/effect-of-timing-of-implementation-of-the-lockdown-on-the-number-of-deaths-for-covid-19-in-four-european-countries\/\",\"url\":\"https:\/\/repo.epiprev.it\/index.php\/2020\/10\/20\/effect-of-timing-of-implementation-of-the-lockdown-on-the-number-of-deaths-for-covid-19-in-four-european-countries\/\",\"name\":\"Effect of timing of implementation of the lockdown on the number of deaths for COVID-19 in four European countries - E&amp;P Repository\",\"isPartOf\":{\"@id\":\"https:\/\/repo.epiprev.it\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/repo.epiprev.it\/index.php\/2020\/10\/20\/effect-of-timing-of-implementation-of-the-lockdown-on-the-number-of-deaths-for-covid-19-in-four-european-countries\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/repo.epiprev.it\/index.php\/2020\/10\/20\/effect-of-timing-of-implementation-of-the-lockdown-on-the-number-of-deaths-for-covid-19-in-four-european-countries\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/repo.epiprev.it\/wp-content\/uploads\/2020\/10\/Barone-Adesi.jpg\",\"datePublished\":\"2020-10-20T08:22:42+00:00\",\"description\":\"We found that a more rapid and homogeneous response would have avoided a substantial number of deaths. 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