Burden of disease in Tuscany: aims and methods of the ACAB project

Publication date: 28/01/2025 – E&P Code: repo.epiprev.it/2890
Authors: Giulia Carreras¹, Miriam Levi², Michela Baccini³

Abstract:
The ACAB Project (“Attributable CAncer Burden in Tuscany: smoking, environmental and occupational risk factors, and evaluation of prevention strategies”) is a three-year scientific initiative funded by the Tuscany Region under the 2018 Bando Ricerca Salute. In this article we illustrate the project main aims and outcomes, and we describe methodological issues and data sources.
The main goal of this project is to produce an updated estimate of the burden of disease for the leading causes of death in Tuscany (Italy), and, focusing on cancers, to estimate the burden of disease due to smoking, ambient air pollution and occupational risk factors. The burden of disease is quantified for the Tuscan population as a whole and by subareas in terms of years of life lost due to premature death, of years lived with disability and in terms of their sum, i.e. disability adjusted life years. All the results are presented with a careful measure of uncertainty.
The project results, which are available on the website www.acab-toscana.it, are useful for health care professionals for the evaluation and communication regarding the main risk factors for the population, and provide support to the development of informed prevention plans.

Cite as: Giulia Carreras, Miriam Levi, Michela Baccini (2025). Burden of disease in Tuscany: aims and methods of the ACAB project. E&P Repository https://repo.epiprev.it/2890

Topic: AMBIENTE E SALUTE

Key words: burden of disease, cancer, chronic diseases, fattori di rischio ambientali,

AVVERTENZA. GLI ARTICOLI PRESENTI NEL REPOSITORY NON SONO SOTTOPOSTI A PEER REVIEW.

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Affiliations:
¹ Istituto per lo Studio, la Prevenzione e la Rete Oncologica, Florence, 50139 Italy.
² UFC Epidemiologia, Dipartimento della Prevenzione, Azienda USL Toscana Centro, Florence, 50135 Italy.
³ Dipartimento di Statistica, Informatica, Applicazioni “Giuseppe Parenti” (DiSIA), University of Florence, Florence, 50134, Italy

Authors’ contributions: –

Competing interests: The authors declare no competing interests

Funding disclosure: This study was funded by Tuscany Region within the Bando Ricerca Salute 2018.

Ethics committee approval: The study received ethics committee approval from Comitato Etico Regionale per la Sperimentazione Clinica della Regione Toscana, Sezione: AREA VASTA CENTRO10/05/2022 (22207_oss).

Copyright: Il detentore del copyright è l’autore/finanziatore, che ha concesso a “E&P Repository” una licenza per rendere pubblico questo preprint. The copyright holder for this preprint is the author/funder, who has granted E&P Repository a license to display the preprint in perpetuity.

Terms of distribution: No riutilizzo

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Figure 1 - Maps of A) the days of life lost pro-capite for tracheal, bronchus, and lung cancer B) the days of life lost pro-capite for tracheal, bronchus, and lung cancer attributable to smoking in 2022 in Tuscany in both sexes, by sanitary district.

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