Tag: virus

UV-C irradiation is highly effective in inactivating and inhibiting SARS-CoV-2 replication

Publication date: 08/06/2020 – E&P Code: repo.epiprev.it/1750
Authors: Andrea Bianco1, Mara Biasin2, Giovanni Pareschi1, Adalberto Cavalieri3, Claudia Cavatorta3, Claudio Fenizia2, Paola Galli1, Luigi Lessio4 , Manuela Lualdi3, Edoardo Redaelli1, Irma Saulle2,5, Daria Trabattoni2, Alessio Zanutta1, Mario Clerici5,6

Abstract: The potential virucidal effects of UV-C irradiation on SARS-CoV-2 were experimentally evaluated for different illumination doses and virus concentrations (1000, 5, 0.05 MOI). Both virus inactivation and replication inhibition were investigated as a function of these parameters. At a virus density comparable to that observed in SARS-CoV-2 infection, an UV-C dose of just 3.7 mJ/cm2 was sufficient to achieve a 3 log inactivation, and complete inhibition of all viral concentrations was observed with 16.9 mJ/cm2. These results could explain the epidemiological trends of COVID-19 and are important for the development of novel sterilizing methods to contain SARS-CoV-2 infection.

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Potential effects of airborne particulate matter on spreading, pathophysiology and prognosis of a viral respiratory infection

Publication date: 02/04/2020 – E&P Code: repo.epiprev.it/688
Authors: Simona Re1, Angelo Facchini2

Abstract. Scientific studies show evidence of a correlation between air pollution levels and respiratory diseases, with a possible increase in the morbidity of respiratory viral infections. However, following the outbreak of Covid-19, the possible effects of the PM (particulate matter) concentrations on the susceptability and pollution-mediated effects are not scientifically demonstrated yet.
In order to shed light on this topic, we performed a narrative review of the scientific literature upon the potential effects of PM on spreading, pathophysiology and prognosis of viral respiratory infections related to Covid-19.
We discuss four hypotheses: 1) how can air pollutants affect the prognosis of respiratory infectious diseases; 2) how can the interaction between air pollutants and pathogens increase the infectious potential of respiratory pathogens; 3) how can air pollutants foster the infectious potential of respiratory pathogens by veiculating them; 4) how can air pollutants worsen the respiratory co-infections by increasing antibiotic resistance.

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